Top 8

The CDC’s 8 Most Concerning Zoonotic Diseases in the United States

Pathogen(s)

Influenza A viruses (e.g., H1N1 or H5N1)

Involved Animals

Pigs, wild birds, or poultry (e.g., chickens)

Transmission

Close contact with infected animals or subsequently infected people

Signs & Symptoms

Salmonellosis

Pathogen(s)

Salmonella bacteria

Involved Animals

Livestock (e.g., cattle or poultry)

Transmission

Consumption of undercooked or unwashed eggs, meat, vegetables, or other foods contaminated with feces

Signs & Symptoms

West Nile fever

Pathogen(s)

West Nile virus

Involved Animals

Wild birds or horses

Transmission

Mosquito bite

Signs & Symptoms

Plague

Pathogen(s)

Yersinia pestis bacterium

Involved Animals

Wild rodents or cats

Transmission

Flea bite

Signs & Symptoms

Emerging coronaviruses

Pathogen(s)

Coronaviruses (e.g., SARS-CoV-2 or MERS-CoV)

Involved Animals

Bats, camels, or civets

Transmission

Close contact with infected animals or subsequently infected people

Signs & Symptoms

Rabies

Pathogen(s)

Rabies lyssavirus

Involved Animals

Dogs, cats, bats, cattle, horses, raccoons, or skunks

Transmission

Animal bites or scratches

Signs & Symptoms

Brucellosis

Pathogen(s)

Brucella bacteria

Involved Animals

Cattle, bison, elk, or wild swine

Transmission

Consumption of infected milk products or direct contact with infected animals

Signs & Symptoms

Lyme disease

Pathogen(s)

Borrelia burgdorferi bacterium

Involved Animals

Mice, deer, birds, lizards, or dogs

Transmission

Tick bite

Signs & Symptoms

Sources

Bauerfeind, R., Von Graevenitz, A., Kimmig, P., Schiefer, H. G., Schwarz, T., Slenczka, W., & Zahner, H. (Eds.). (2016). Zoonoses: Infectious Diseases Transmissible Between Animals and Humans. ASM Press. (Original work published 2013)

U.S. Department of Health and Human Services, U.S. Department of Agriculture, & U.S. Department of the Interior. (2019). Prioritizing Zoonotic Diseases for Multisectoral, One Health Collaboration in the United States: Workshop Summary. https://www.cdc.gov/onehealth/pdfs/us-ohzdp-report-508.pdf

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